AESCIN is a mixture of saponin, extracted from horse chestnut, from its seeds, bark, and leaves. It is used in the manufacture of the drug for its combination of anti-inflammatory, extended and vascular-protecting properties. The mechanism of action of Essen depends on the fluidization of blood, the current fluid leakage from the veins and capillaries, where it targets the walls of blood vessels, so that it reduces fluid loss into the urine to help prevent reflux.