Zestoretic is used to treat high blood pressure (hypertension). It contains two medicines called lisinopril and hydrochlorothiazide.Lisinopril belongs to a group of medicines called ACE inhibitors. It works by making your blood vessels widen.Hydrochlorothiazide belongs to a group of medicines called diuretics (water tablets). It helps your body to get rid of water and salts like sodium in your urine.
These medicines work together to lower your blood pressure

Swallow the tablet with a drink of water.
Try to take your tablets at the same time each day. It does not matter if you take Zestoretic before or after food.
Keep taking Zestoretic for as long as your doctor tells you to, it is a long term treatment. It is important to keep taking Zestoretic every day.